Qianqian Su
Southeast University, CHINA
Title: Rationally Designed Plasmonic Nanostructures for Biosensing
Biography
Biography: Qianqian Su
Abstract
Gold nanostars, as one of plasmonic nanostructures, have been recently reported to yield extraordinary field enhancements for SERS, especially at the tip of their branches. It has been reported that gold nanostars show stronger SERS enhancement than nanorods and nanospheres under similar experimental conditions. Thus, the combination of these two aspects may provide a solution to the fabrication of a low-cost, large-scale, and reproducible SERS active substrate. We study the assembly of gold nanostars as reproducible SERS substrates via electrostatically assisted APTES-functionalized surface-assembly method and detect the SERS activities. The gold nanostars were immobilized on ITO surface by using electrostatically assisted APTES-functionalized surface-assembly as SERS active substrates. A comparison of these substrates’ optical characteristics and SERS efficiency as a function of branch length was made, and the potential use of these substrates in quantitative detection applications was also investigated. There are two main advantages of our substrates: firstly, the fabricating progress of this substrate is simple, low-cost, reproducible, and equipment-independent, thus it is possible for large-scale production, even for commercial manufacture; secondly, the obtained substrates have extremely good uniformity, which is preponderant for biosensing. Moreover, by employing the TAT Peptideconjugated Au nanostars (AuNSs) as an intracellular probe, we developed a method for the identification of LR-MSC differentiation by surface-enhanced Raman scattering (SERS) spectroscopy. By PCA analysis of the SERS spectra, we have demonstrated that cellular components and cytoarchitecture have been changed during differentiation.